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Información del Artículo

Título:
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Molecular mechanisms of angiogenesis: Experimental models define cellular trafficking of FGF-1
Autores:
En: PUERTO RICO HEALTH SCIENCES JOURNAL, 15 (3) Sept. 1996: 179-186. bibl. fotos.
Revista: Puerto Rico health sciences journal, vol. 15, núm. 3; Sept. 1996
Resumen: Numerous studies have established that stimulation of cell growth by members of the fibroblast growth (FGF) family of polypeptides is dependent upon an extracellular pathway. Acidic FGF (FGF-1), however, lacks a classical signal sequence for secretion, thereby making it difficult to evaluate regulation of biological activity by this growth factor.
Resumen: Efforts in this laboratory have utilized molecular techniques of retrovirology and transgenic modeling to introduce cDNA sequences encoding either an intracellular or extracellular form of FGF-1 into primary diploid cells to examine trafficking and compartmentalization of FGF-1.
Resumen: Several lines of evidence obtained from these models provide a compelling argument that the stimulation of FGF-1-associated cellular transformation is restricted to an extracellular, receptor-mediated pathway, involving protein tyrosine phosphorylation and nuclear localization. In addition, an unconventional secretion pathway for intracellular FGF-1 has been identified that involves mechanisms associated with oxidative stess.
Notas: Key words: Fibroblast growth factor, Fibroblast growth factor, receptor Retroviral gene transfer, Transgenic techniques, Cell transformation, Nuclear transport, Lens differentiation, HIV-1 TAT, Oxidative stress.
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